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HelpTest ID: ABYSR Antibody Screen with Reflexed Antibody Identification, Blood
Shipping Instructions
Specimen must arrive within 72 hours of collected.
Specimen Required
Container/Tube: Pink top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Useful For
Detection of allo- or autoantibodies directed against red blood cell antigens in the settings of pretransfusion testing
Evaluation of transfusion reactions
Evaluation of hemolytic anemia
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ABIDR | Antibody Identification, RBC | Yes | No |
| ABTIR | Antibody Titer, RBC | Yes | No |
Testing Algorithm
If the antibody screen is positive, then antibody identification will be performed.
If the patient has a history of antibodies that are still detected, the antibody screen will be canceled and replaced by the antibody identification.
If certain antibodies are detected and the patient is known to be pregnant, an antibody titration will be performed.
Method Name
Hemagglutination
Reporting Name
Antibody Screen, RBCSpecimen Type
Whole Blood EDTASpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Refrigerated (preferred) | 4 days | |
| Ambient | 4 days |
Clinical Information
Transfusion and pregnancy are the primary means of sensitization to red cell antigens. In a given population, 2% to 4% of the general population possess irregular red cell alloantibodies. Such antibodies may cause hemolytic disease of the newborn or hemolysis of transfused donor red blood cells.
Reference Values
Negative
If positive, antibody identification will be performed.
Interpretation
A positive result (antibody detected) necessitates antibody identification to establish the specificity and clinical significance of the antibody detected.
Alloantibodies detected on pregnant Mayo Clinic-Rochester patients will be evaluated for the allo-antibody titer. If antibody reacts strongly, the titre test will be performed.
Negative results indicate no antibody was detected.
Clinical Reference
Cohn CS, et al. Technical Manual. 21st ed. AABB; 2023
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86850
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ABYSR | Antibody Screen, RBC | 101678-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| ABYSR | Antibody Screen, RBC | 890-4 |
Forms
If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 2 daysmml-benign-hematology-disorders