Sign in →

Test ID: UNHB Hemoglobin Stability, Blood

Reporting Name

Hb Stability, B

Useful For

Work-up of congenital hemolytic anemias

Specimen Type

Whole Blood EDTA


Specimen Required


Only orderable as part of a profile or as a reflex. For more information see:

-HAEV1 / Hemolytic Anemia Evaluation, Blood

-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood

-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood

-REVE1 / Erythrocytosis Evaluation, Whole Blood

-MEV1 / Methemoglobinemia Evaluation, Blood

 

Container/Tube: Lavender top (EDTA)

Specimen Volume: 4 mL


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated 7 days

Reference Values

Only orderable as part of a profile or as a reflex. For more information see:

-HAEV1 / Hemolytic Anemia Evaluation, Blood

-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood

-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood

-REVE1 / Erythrocytosis Evaluation, Whole Blood

-MEV1 / Methemoglobinemia Evaluation, Blood

  

Normal (reported as normal [stable] or abnormal [unstable])

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83068

LOINC Code Information

Test ID Test Order Name Order LOINC Value
UNHB Hb Stability, B 4639-1

 

Result ID Test Result Name Result LOINC Value
9095 Hb Stability, B 4639-1

Clinical Information

Unstable hemoglobin disease is rare and may be caused by any 1 of a large number of hemoglobin variants. They are inherited as an autosomal dominant trait. The severity of the disease varies according to the hemoglobin variant; there may be no clinical symptoms or the disease may produce a mild, moderate, or severe hemolytic anemia.

 

The stained peripheral blood smear shows anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia. The reticulocyte count may be increased. Splenomegaly and Heinz bodies may also be present.

Interpretation

An abnormal or unstable result is indicative of a hemoglobin variant present. Other confirmatory tests should be performed to identify the hemoglobinopathy (HBEL1 / Hemoglobin Electrophoresis Cascade, Blood).

Clinical Reference

1. Hoyer JD, Hoffman DR: The thalassemia and hemoglobinopathy syndromes. In: McClatchey KD, Amin HM, Curry JL, eds. Clinical Laboratory Medicine. 2nd ed. Lippincott Williams and Wilkins; 2002:866-895

2. Benz EJ, Ebert BL: Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias. In: Hoffman R, Benz EJ, Silberstein LE, et al: eds. Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018:608-615

Method Name

Only orderable as part of a profile or as a reflex. For more information see:

-HAEV1 / Hemolytic Anemia Evaluation, Blood

-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood

-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood

-REVE1 / Erythrocytosis Evaluation, Whole Blood

-MEV1 / Methemoglobinemia Evaluation, Blood

 

Isopropanol and Heat Stability

Mayo Clinic Laboratories | Hematology Catalog Additional Information:

mml-benign-hematology-disorders